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DOI:10.3762/bjoc.10.117 - Corpus ID: 11488829
@article{Lecorre2014AthertonToddRM, title={Atherton–Todd reaction: mechanism, scope and applications}, author={St{\'e}phanie Le corre and Mathieu Berchel and H{\'e}l{\`e}ne Couthon-Gourv{\`e}s and Jan Haelters and Paul-Alain Jaffr{\`e}s}, journal={Beilstein Journal of Organic Chemistry}, year={2014}, volume={10}, pages={1166 - 1196}, url={https://api.semanticscholar.org/CorpusID:11488829}}
- S. Le corre, M. Berchel, P. Jaffrès
- Published in Beilstein Journal of Organic… 21 May 2014
- Chemistry
The activation of a phenol group as a phosphate which allows for subsequent transformations such as cross coupling and reduction and the use of the AT reaction for the production of compounds employed for biological applications is investigated.
123 Citations
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123 Citations
- V. MitovaN. KosevaK. Troev
- 2014
Chemistry
A new mechanism of the Atherton–Todd reaction is discussed. The first step of the reaction between diesters of H-phosphonic acid and carbon tetrachloride in the presence of a base, commonly…
- A. JasiakKrzysztof OwsianikBartłomiej GostyńskiG. MielniczakC. StevensJ. Drabowicz
- 2020
Chemistry
An efficient and catalyst-free method for the preparation of optically active and racemic mono-substituted t-butyl phosphinic chlorides tBuRP(O)Cl under flow conditions was reported. A variety of…
- PDF
- K. Troev
- 2018
Chemistry
- Xunwei ChenZecai XiaoHan-Yang ChuBo-Chi WangA. Peng
- 2018
Chemistry
Investigation of the iodine-mediated phosphoramidation reaction of amines and trialkyl phosphites shows that this underused method is actually a mild, practical and general way to synthesizeosphoramidates and will have wide applications.
- 10
- Karen R. WintersJean-Luc Montchamp
- 2020
Chemistry
The Journal of organic chemistry
Two major approaches were selected: the Stec reaction of phosphorus amides with carbon disulfide; and the one-pot synthesis of thiophosphorus acids from H-phosphinates, an organometallic nucleophile, and quenching with elemental sulfur.
- 3
- PDF
- Wang DaiQiangqiang Liu S. Cao
- 2016
Chemistry
The Atherton–Todd-type reaction of hydrospirophosphoranes (HSPs) and sodium alcoholates was investigated. Direct alkoxylation of HSPs was accomplished with sodium alcoholates in acetonitrile under…
- 9
- Lvyin ZhengLiuhuan Cai Wei Guo
- 2022
Chemistry, Medicine
The Journal of organic chemistry
This work reported here represents a direct P(═O)-N-N bond formation with the advantages of being operationally simple, good functional group tolerance, and high atom and step economy.
- 7
- HandokoZacharia BenslimaneP. Arora
- 2020
Chemistry
Organic letters
A diaryldiselenide catalyst for cross-dehydrogenative nucleophilic functionalization of hydrophosphoryl compounds and phosphorus and selenium NMR studies reveal the existence of a P-Se bond intermediate, and structural analyses indicate a stereospecific reaction.
- 26
- N. A. DangrooTabassum AraB. DarMohmmed A Khuroo
- 2019
Chemistry
Catalysis Communications
- 10
- Chen TanXinyuan Liu Jiajing Tan
- 2019
Chemistry
Chemistry
This operationally simple protocol provides unprecedented generic access to phosphinic amides/phosphoramidate derivatives in good yields and short reaction time and is applicable to scale-up syntheses as well as late stage functionalization of drug molecules.
- 27
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We were the first to perform phosphorylation of amino(aryl)methylphosphonates having a primary amino group under the Atherton–Todd reaction conditions. The reactions of amino(aryl)methylphosphonates…
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Chemistry
This article discusses the behavior of seven organophosphorus compounds under Atherton–Todd conditions. Therefore, the reactivity and selectivity of different (phen)oxaphosphinines,…
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The asymmetric aldol addition is among the most powerful reactions in synthetic organic chemistry and has been extensively studied over the past 15 years.1 The strategies for reagentcontrolled…
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Chemistry
The Journal of organic chemistry
The Atherton-Todd-type reaction of pentacoordinate hydrospirophosphoranes with amines was investigated, and a novel CO2 insertion reaction into the pentacoordinate P-N bond under mild conditions was…
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A facile method for the synthesis of nonsymmetrical dialkylamines (CnH2n+1)2NH (n = 1–12) using the Ph2P(O) protecting group was developed. The method includes successive transformation of…
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Chemistry
Russian Journal of General Chemistry
Mechanism of the synthesis of phosphoramidates by Todd-Atherton reaction is based on the primary interaction of a polyhaloalkane with the highly basic amine to form a 1:1 associate. The subsequent…
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Chemistry
The Journal of organic chemistry
Both chiral and achiral phosphoramides of diverse structure were prepared from diamines by the coupling to phosphorus(V) or phosphorus(III) reagents. Several enantiopure…
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Chemistry
The Journal of organic chemistry
Short protocols for assembling (S,S)-isodityrosine and K-13 are developed on the basis of studies on coupling reaction of L-tyrosine derivatives and L-phenylalanine-derived iodides and reaction yields are moderate.
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